Drug interactions
Insulin degludec-insulin aspart + Pentamidine
Severity: Moderate
Insulin degludec-insulin aspart and Pentamidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine can damage pancreatic beta cells, causing an initial insulin release with hypoglycemia that may later be followed by hyperglycemia or diabetes. In a patient on insulin, glucose control may therefore become unpredictable during and after pentamidine treatment.
What this interaction means in plain words
Insulin degludec-insulin aspart and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Pentamidine belongs to Anti Parasitic.
Why it happens
Pentamidine is toxic to pancreatic beta cells, causing early insulin release and later insulin deficiency.
What to do
Monitor blood glucose closely during and for some time after pentamidine therapy. Reduce insulin if hypoglycemia occurs and increase it if hyperglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Pentamidine?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentamidine can damage pancreatic beta cells, causing an initial insulin release with hypoglycemia that may later be followed by hyperglycemia or diabetes. In a patient on insulin, glucose control may therefore become unpredictable during and after pentamidine treatment.
How serious is the interaction between Insulin degludec-insulin aspart and Pentamidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during and for some time after pentamidine therapy. Reduce insulin if hypoglycemia occurs and increase it if hyperglycemia develops.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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