Drug interactions
Insulin degludec-insulin aspart + Prochlorperazine
Severity: Minor
Insulin degludec-insulin aspart and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines such as prochlorperazine may increase blood glucose and blunt the effect of insulin. The effect is usually modest and mainly relevant with prolonged use.
What this interaction means in plain words
Insulin degludec-insulin aspart and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin degludec-insulin aspart belongs to Endocrine; Prochlorperazine belongs to Central Nervous System.
Why it happens
Phenothiazines may reduce insulin secretion and sensitivity; mechanism is incompletely defined.
What to do
Monitor blood glucose with sustained use and adjust insulin if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Prochlorperazine?
MediHelp rates the interaction as minor. Insulin degludec-insulin aspart and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazines such as prochlorperazine may increase blood glucose and blunt the effect of insulin. The effect is usually modest and mainly relevant with prolonged use.
How serious is the interaction between Insulin degludec-insulin aspart and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose with sustained use and adjust insulin if control worsens.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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