Drug interactions
Insulin degludec-insulin aspart + Sotagliflozin
Severity: Moderate
Insulin degludec-insulin aspart and Sotagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding sotagliflozin to insulin increases the risk of hypoglycemia. Sotagliflozin also carries a risk of diabetic ketoacidosis, which is relevant when insulin doses are lowered.
What this interaction means in plain words
Insulin degludec-insulin aspart and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-insulin aspart belongs to Endocrine; Sotagliflozin belongs to Endocrine.
Why it happens
Additive glucose lowering, since sotagliflozin promotes urinary glucose excretion and inhibits intestinal glucose absorption in addition to insulin action.
What to do
Consider a modest insulin dose reduction when starting sotagliflozin and monitor glucose closely. Avoid excessive insulin reduction and monitor for ketoacidosis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Sotagliflozin
- Carbamazepine + Sotagliflozin Moderate
- Chlorpropamide + Sotagliflozin Moderate
- Digoxin + Sotagliflozin Moderate
- Gliclazide + Sotagliflozin Moderate
- Glimepiride-pioglitazone + Sotagliflozin Moderate
- Glimepiride + Sotagliflozin Moderate
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Sotagliflozin?
MediHelp rates the interaction as moderate. Insulin degludec-insulin aspart and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding sotagliflozin to insulin increases the risk of hypoglycemia. Sotagliflozin also carries a risk of diabetic ketoacidosis, which is relevant when insulin doses are lowered.
How serious is the interaction between Insulin degludec-insulin aspart and Sotagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a modest insulin dose reduction when starting sotagliflozin and monitor glucose closely. Avoid excessive insulin reduction and monitor for ketoacidosis symptoms.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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