Drug interactions
Insulin glargine + Sotagliflozin
Severity: Moderate
Insulin glargine and Sotagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotagliflozin with insulin increases the risk of hypoglycemia, and ketoacidosis risk must also be considered.
What this interaction means in plain words
Insulin glargine and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine belongs to Endocrine; Sotagliflozin belongs to Endocrine.
Why it happens
Additive glucose lowering from insulin and SGLT-mediated urinary glucose excretion.
What to do
Consider lowering the insulin dose when starting sotagliflozin and monitor glucose and ketones.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Sotagliflozin
- Carbamazepine + Sotagliflozin Moderate
- Chlorpropamide + Sotagliflozin Moderate
- Digoxin + Sotagliflozin Moderate
- Glibenclamide + Sotagliflozin Moderate
- Gliclazide + Sotagliflozin Moderate
- Glimepiride-pioglitazone + Sotagliflozin Moderate
Frequently asked questions
Can I take Insulin glargine with Sotagliflozin?
MediHelp rates the interaction as moderate. Insulin glargine and Sotagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotagliflozin with insulin increases the risk of hypoglycemia, and ketoacidosis risk must also be considered.
How serious is the interaction between Insulin glargine and Sotagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the insulin dose when starting sotagliflozin and monitor glucose and ketones.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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