Drug interactions
Ivacaftor + Mitomycin
Severity: Minor
Ivacaftor and Mitomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor and its M1 metabolite weakly inhibit P-glycoprotein, which may modestly increase exposure to P-gp substrates such as mitomycin. This could enhance myelosuppression or other toxicity, though the effect on mitomycin has not been studied.
What this interaction means in plain words
Ivacaftor and Mitomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivacaftor belongs to Miscellaneous; Mitomycin belongs to Oncology.
Why it happens
Ivacaftor inhibits P-glycoprotein efflux, potentially decreasing mitomycin efflux and clearance.
What to do
Monitor complete blood counts and for mitomycin toxicity during co-therapy. Reduce the mitomycin dose if excess toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Mitomycin?
MediHelp rates the interaction as minor. Ivacaftor and Mitomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor and its M1 metabolite weakly inhibit P-glycoprotein, which may modestly increase exposure to P-gp substrates such as mitomycin. This could enhance myelosuppression or other toxicity, though the effect on mitomycin has not been studied.
How serious is the interaction between Ivacaftor and Mitomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and for mitomycin toxicity during co-therapy. Reduce the mitomycin dose if excess toxicity occurs.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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