Drug interactions
Ivermectin + Levoketoconazole
Severity: Minor
Ivermectin and Levoketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole inhibits CYP3A4 and P-glycoprotein and may increase ivermectin concentrations. Clinical significance is likely small because of ivermectin's wide safety margin.
What this interaction means in plain words
Ivermectin and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivermectin belongs to Anti Parasitic; Levoketoconazole belongs to Endocrine.
Why it happens
Levoketoconazole inhibits CYP3A4 metabolism and P-glycoprotein efflux of ivermectin.
What to do
No routine dose change is needed. Monitor for CNS or gastrointestinal adverse effects of ivermectin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Ivermectin with Levoketoconazole?
MediHelp rates the interaction as minor. Ivermectin and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levoketoconazole inhibits CYP3A4 and P-glycoprotein and may increase ivermectin concentrations. Clinical significance is likely small because of ivermectin's wide safety margin.
How serious is the interaction between Ivermectin and Levoketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for CNS or gastrointestinal adverse effects of ivermectin.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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