Drug interactions
Ivermectin + Stiripentol
Severity: Minor
Ivermectin and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits P-glycoprotein in vitro and could increase ivermectin exposure. The expected effect is small and ivermectin is generally well tolerated at higher exposures.
What this interaction means in plain words
Ivermectin and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivermectin belongs to Anti Parasitic; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol may inhibit P-gp efflux of ivermectin, raising its plasma and tissue concentrations.
What to do
No preemptive adjustment is needed. Monitor for CNS or gastrointestinal adverse effects and consider reducing ivermectin dosing if they develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Other interactions of Stiripentol
Frequently asked questions
Can I take Ivermectin with Stiripentol?
MediHelp rates the interaction as minor. Ivermectin and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits P-glycoprotein in vitro and could increase ivermectin exposure. The expected effect is small and ivermectin is generally well tolerated at higher exposures.
How serious is the interaction between Ivermectin and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No preemptive adjustment is needed. Monitor for CNS or gastrointestinal adverse effects and consider reducing ivermectin dosing if they develop.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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