Drug interactions
Ixazomib + Posaconazole
Severity: Minor
Ixazomib and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ixazomib is partly metabolised by CYP3A4, but studies with strong CYP3A inhibitors showed no clinically meaningful change in exposure. No relevant clinical effect is expected.
What this interaction means in plain words
Ixazomib and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ixazomib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Theoretical CYP3A4 inhibition with negligible effect on ixazomib exposure.
What to do
No dose adjustment is required; monitor routinely for ixazomib toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
Frequently asked questions
Can I take Ixazomib with Posaconazole?
MediHelp rates the interaction as minor. Ixazomib and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ixazomib is partly metabolised by CYP3A4, but studies with strong CYP3A inhibitors showed no clinically meaningful change in exposure. No relevant clinical effect is expected.
How serious is the interaction between Ixazomib and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor routinely for ixazomib toxicity.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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