Drug interactions
Ixazomib + Tucatinib
Severity: Minor
Ixazomib and Tucatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and may raise ixazomib levels. Ixazomib labeling does not require dose adjustment for CYP3A inhibitors, so the clinical effect is likely modest.
What this interaction means in plain words
Ixazomib and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ixazomib belongs to Oncology; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing ixazomib metabolism, although CYP3A contributes only partly to ixazomib clearance at clinical concentrations.
What to do
No dose change is required; monitor for ixazomib toxicities such as thrombocytopenia, diarrhea and neuropathy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Ixazomib with Tucatinib?
MediHelp rates the interaction as minor. Ixazomib and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tucatinib inhibits CYP3A4 and may raise ixazomib levels. Ixazomib labeling does not require dose adjustment for CYP3A inhibitors, so the clinical effect is likely modest.
How serious is the interaction between Ixazomib and Tucatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required; monitor for ixazomib toxicities such as thrombocytopenia, diarrhea and neuropathy.
What other medicines interact with Ixazomib?
MediHelp also lists interactions of Ixazomib with, for example, Apalutamide, Carbamazepine, Dabrafenib. The full list is on the Ixazomib page.
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