Drug interactions
Labetalol + Silodosin
Severity: Moderate
Labetalol and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol has alpha-1 and beta-blocking activity, so combining it with silodosin adds to alpha-1 blockade. Orthostatic hypotension, dizziness and syncope are more likely, particularly when starting or increasing doses.
What this interaction means in plain words
Labetalol and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Labetalol belongs to Cardiovascular; Silodosin belongs to Genitourinary.
Why it happens
Additive alpha-1 adrenergic blockade together with beta-blockade producing summed hypotensive effects.
What to do
Check standing blood pressure after starting or changing either drug and titrate slowly. Reduce the dose of one agent if orthostatic symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Labetalol with Silodosin?
MediHelp rates the interaction as moderate. Labetalol and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol has alpha-1 and beta-blocking activity, so combining it with silodosin adds to alpha-1 blockade. Orthostatic hypotension, dizziness and syncope are more likely, particularly when starting or increasing doses.
How serious is the interaction between Labetalol and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check standing blood pressure after starting or changing either drug and titrate slowly. Reduce the dose of one agent if orthostatic symptoms develop.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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