Drug interactions
Lacosamide + Posaconazole
Severity: Minor
Lacosamide and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lacosamide is partly metabolised by CYP3A4 and other enzymes, so posaconazole may modestly increase its exposure. This could add to dizziness, ataxia and PR interval prolongation, though the effect is usually small.
What this interaction means in plain words
Lacosamide and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lacosamide belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4, one of several pathways for lacosamide clearance.
What to do
No routine dose change is needed. Monitor for dizziness, ataxia and conduction abnormalities, and reduce the lacosamide dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Frequently asked questions
Can I take Lacosamide with Posaconazole?
MediHelp rates the interaction as minor. Lacosamide and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lacosamide is partly metabolised by CYP3A4 and other enzymes, so posaconazole may modestly increase its exposure. This could add to dizziness, ataxia and PR interval prolongation, though the effect is usually small.
How serious is the interaction between Lacosamide and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for dizziness, ataxia and conduction abnormalities, and reduce the lacosamide dose if they occur.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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