Drug interactions
Leflunomide + Stiripentol
Severity: Moderate
Leflunomide and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits BCRP and may increase teriflunomide exposure. This may increase leflunomide adverse effects such as hepatotoxicity.
What this interaction means in plain words
Leflunomide and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leflunomide belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits BCRP-mediated transport of teriflunomide.
What to do
Monitor liver enzymes and for leflunomide adverse effects. Reduce the leflunomide dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Leflunomide with Stiripentol?
MediHelp rates the interaction as moderate. Leflunomide and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits BCRP and may increase teriflunomide exposure. This may increase leflunomide adverse effects such as hepatotoxicity.
How serious is the interaction between Leflunomide and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and for leflunomide adverse effects. Reduce the leflunomide dose if toxicity occurs.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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