Drug interactions
Leflunomide + Vadadustat
Severity: Moderate
Leflunomide and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits BCRP and may increase exposure to teriflunomide, the active metabolite of leflunomide. This may increase leflunomide-related adverse effects such as hepatotoxicity.
What this interaction means in plain words
Leflunomide and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leflunomide belongs to Musculoskeletal; Vadadustat belongs to Endocrine.
Why it happens
Vadadustat inhibits BCRP efflux, raising teriflunomide concentrations.
What to do
Monitor for leflunomide adverse effects and liver enzymes. Reduce the leflunomide dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Leflunomide with Vadadustat?
MediHelp rates the interaction as moderate. Leflunomide and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat inhibits BCRP and may increase exposure to teriflunomide, the active metabolite of leflunomide. This may increase leflunomide-related adverse effects such as hepatotoxicity.
How serious is the interaction between Leflunomide and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for leflunomide adverse effects and liver enzymes. Reduce the leflunomide dose if needed.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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