Drug interactions
Lenvatinib + Leuprolide
Severity: Moderate
Lenvatinib and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenvatinib can prolong the QT interval, and leuprolide may contribute an additional effect. The combination increases the chance of arrhythmia, particularly with electrolyte abnormalities.
What this interaction means in plain words
Lenvatinib and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lenvatinib belongs to Oncology; Leuprolide belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG and electrolytes regularly and correct hypokalemia, hypomagnesemia and hypocalcemia. Interrupt or reduce lenvatinib if QTc is markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Lenvatinib with Leuprolide?
MediHelp rates the interaction as moderate. Lenvatinib and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenvatinib can prolong the QT interval, and leuprolide may contribute an additional effect. The combination increases the chance of arrhythmia, particularly with electrolyte abnormalities.
How serious is the interaction between Lenvatinib and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes regularly and correct hypokalemia, hypomagnesemia and hypocalcemia. Interrupt or reduce lenvatinib if QTc is markedly prolonged.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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