Drug interactions
Leuprolide + Lopinavir
Severity: Moderate
Leuprolide and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir can prolong the QT and PR intervals, and leuprolide may add to QT prolongation. The combination may raise the risk of arrhythmia, especially with other risk factors.
What this interaction means in plain words
Leuprolide and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leuprolide belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
Additive QT prolongation from androgen deprivation (leuprolide) and lopinavir effects on cardiac repolarization.
What to do
Obtain a baseline ECG and monitor the QTc during combined therapy. Correct electrolyte abnormalities and avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Leuprolide with Lopinavir?
MediHelp rates the interaction as moderate. Leuprolide and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir can prolong the QT and PR intervals, and leuprolide may add to QT prolongation. The combination may raise the risk of arrhythmia, especially with other risk factors.
How serious is the interaction between Leuprolide and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc during combined therapy. Correct electrolyte abnormalities and avoid adding other QT-prolonging drugs.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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