Drug interactions
Leuprolide + Mirtazapine
Severity: Moderate
Leuprolide and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with leuprolide can prolong the QT interval, and mirtazapine adds a modest effect of its own. The combination may increase arrhythmia risk in susceptible patients.
What this interaction means in plain words
Leuprolide and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leuprolide belongs to Endocrine; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive QT prolongation; androgen deprivation alters cardiac repolarization.
What to do
Review baseline ECG and electrolytes in patients with cardiac risk factors, and correct any abnormalities. Repeat the ECG if further QT-prolonging drugs are added.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Leuprolide with Mirtazapine?
MediHelp rates the interaction as moderate. Leuprolide and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation with leuprolide can prolong the QT interval, and mirtazapine adds a modest effect of its own. The combination may increase arrhythmia risk in susceptible patients.
How serious is the interaction between Leuprolide and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review baseline ECG and electrolytes in patients with cardiac risk factors, and correct any abnormalities. Repeat the ECG if further QT-prolonging drugs are added.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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