Drug interactions
Leuprolide + Ranolazine
Severity: Moderate
Leuprolide and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with leuprolide may prolong the QT interval, and ranolazine has a similar effect. The combination may increase the risk of torsades de pointes, particularly with other risk factors.
What this interaction means in plain words
Leuprolide and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leuprolide belongs to Endocrine; Ranolazine belongs to Cardiovascular.
Why it happens
Additive QT prolongation from androgen deprivation and ranolazine.
What to do
Check a baseline ECG and electrolytes and repeat periodically during therapy. Reconsider the antianginal if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Leuprolide with Ranolazine?
MediHelp rates the interaction as moderate. Leuprolide and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with leuprolide may prolong the QT interval, and ranolazine has a similar effect. The combination may increase the risk of torsades de pointes, particularly with other risk factors.
How serious is the interaction between Leuprolide and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and repeat periodically during therapy. Reconsider the antianginal if QTc becomes markedly prolonged.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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