Drug interactions
Leuprolide + Sevoflurane
Severity: Minor
Leuprolide and Sevoflurane: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with leuprolide may prolong the QT interval and sevoflurane can also affect repolarization. The combined effect is likely small but may matter in patients with other risk factors.
What this interaction means in plain words
Leuprolide and Sevoflurane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Leuprolide belongs to Endocrine; Sevoflurane belongs to Central Nervous System.
Why it happens
Possible additive QT prolongation, with the effect of GnRH agonists being indirect.
What to do
No routine change is needed. Check the baseline ECG and electrolytes in patients with other QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sevoflurane
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Leuprolide with Sevoflurane?
MediHelp rates the interaction as minor. Leuprolide and Sevoflurane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Androgen deprivation with leuprolide may prolong the QT interval and sevoflurane can also affect repolarization. The combined effect is likely small but may matter in patients with other risk factors.
How serious is the interaction between Leuprolide and Sevoflurane?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Check the baseline ECG and electrolytes in patients with other QT risk factors.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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