Drug interactions
Leuprolide + Trazodone
Severity: Moderate
Leuprolide and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leuprolide, as androgen deprivation therapy, can prolong the QT interval, and trazodone adds its own QT risk. The combination may increase the chance of torsades de pointes in susceptible patients.
What this interaction means in plain words
Leuprolide and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leuprolide belongs to Endocrine; Trazodone belongs to Central Nervous System.
Why it happens
Additive QT prolongation through androgen deprivation and trazodone effects on cardiac repolarization.
What to do
Obtain a baseline ECG and correct potassium and magnesium; monitor QTc and avoid further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Leuprolide with Trazodone?
MediHelp rates the interaction as moderate. Leuprolide and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leuprolide, as androgen deprivation therapy, can prolong the QT interval, and trazodone adds its own QT risk. The combination may increase the chance of torsades de pointes in susceptible patients.
How serious is the interaction between Leuprolide and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium; monitor QTc and avoid further QT-prolonging drugs.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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