Drug interactions
Leuprolide + Triclabendazole
Severity: Moderate
Leuprolide and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole can cause QT prolongation, and leuprolide may add to this effect. The combination may raise arrhythmia risk in patients with additional risk factors.
What this interaction means in plain words
Leuprolide and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leuprolide belongs to Endocrine; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain an ECG before treatment in patients with cardiac risk factors and correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Triclabendazole
Frequently asked questions
Can I take Leuprolide with Triclabendazole?
MediHelp rates the interaction as moderate. Leuprolide and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclabendazole can cause QT prolongation, and leuprolide may add to this effect. The combination may raise arrhythmia risk in patients with additional risk factors.
How serious is the interaction between Leuprolide and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before treatment in patients with cardiac risk factors and correct electrolyte abnormalities.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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