Drug interactions
Levamlodipine + Posaconazole
Severity: Moderate
Levamlodipine and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can increase levamlodipine exposure, which may cause hypotension, peripheral edema and dizziness.
What this interaction means in plain words
Levamlodipine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levamlodipine belongs to Cardiovascular; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 reduces metabolism of levamlodipine.
What to do
Monitor blood pressure and for edema when starting or stopping posaconazole. Reduce the levamlodipine dose if hypotension or edema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
Frequently asked questions
Can I take Levamlodipine with Posaconazole?
MediHelp rates the interaction as moderate. Levamlodipine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole can increase levamlodipine exposure, which may cause hypotension, peripheral edema and dizziness.
How serious is the interaction between Levamlodipine and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for edema when starting or stopping posaconazole. Reduce the levamlodipine dose if hypotension or edema occurs.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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