Drug interactions
Levoketoconazole + Medroxyprogesterone
Severity: Moderate
Levoketoconazole and Medroxyprogesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and may substantially increase medroxyprogesterone concentrations. This could amplify progestogenic adverse effects.
What this interaction means in plain words
Levoketoconazole and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Medroxyprogesterone belongs to Endocrine.
Why it happens
Strong inhibition of CYP3A4 metabolism of medroxyprogesterone.
What to do
Monitor for progestogenic adverse effects such as bleeding changes, fluid retention and mood changes. Review the hormonal regimen if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Medroxyprogesterone
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Medroxyprogesterone?
MediHelp rates the interaction as moderate. Levoketoconazole and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and may substantially increase medroxyprogesterone concentrations. This could amplify progestogenic adverse effects.
How serious is the interaction between Levoketoconazole and Medroxyprogesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestogenic adverse effects such as bleeding changes, fluid retention and mood changes. Review the hormonal regimen if they occur.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
Full monographs, dosing and an interaction checker in the MediHelp app
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