Drug interactions
Levoketoconazole + Montelukast
Severity: Minor
Levoketoconazole and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and may increase montelukast exposure. Because CYP2C8 is the main route of montelukast clearance and its therapeutic index is wide, the effect is generally of limited clinical significance.
What this interaction means in plain words
Levoketoconazole and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levoketoconazole belongs to Endocrine; Montelukast belongs to Respiratory.
Why it happens
Levoketoconazole inhibits CYP3A4, a secondary pathway for montelukast metabolism.
What to do
No dose adjustment is generally needed; monitor for increased montelukast adverse effects, especially neuropsychiatric changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Montelukast?
MediHelp rates the interaction as minor. Levoketoconazole and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levoketoconazole is a strong CYP3A4 inhibitor and may increase montelukast exposure. Because CYP2C8 is the main route of montelukast clearance and its therapeutic index is wide, the effect is generally of limited clinical significance.
How serious is the interaction between Levoketoconazole and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor for increased montelukast adverse effects, especially neuropsychiatric changes.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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