Drug interactions
Levoketoconazole + Posaconazole
Severity: Contraindicated
Levoketoconazole and Posaconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are azoles that prolong the QT interval, so combination markedly raises arrhythmia risk. Levoketoconazole is also a strong CYP3A4 inhibitor and its labeling warns against combining it with other QT-prolonging drugs.
What this interaction means in plain words
Levoketoconazole and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levoketoconazole belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation, with inhibition of CYP3A4 and P-gp by levoketoconazole possibly increasing posaconazole exposure.
What to do
Avoid concurrent use. Choose an alternative to one of the agents, and if unavoidable monitor ECG and electrolytes closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Posaconazole?
MediHelp rates the interaction as contraindicated. Levoketoconazole and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs are azoles that prolong the QT interval, so combination markedly raises arrhythmia risk. Levoketoconazole is also a strong CYP3A4 inhibitor and its labeling warns against combining it with other QT-prolonging drugs.
How serious is the interaction between Levoketoconazole and Posaconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. Choose an alternative to one of the agents, and if unavoidable monitor ECG and electrolytes closely.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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