Drug interactions
Levoketoconazole + Progesterone
Severity: Moderate
Levoketoconazole and Progesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and can substantially increase progesterone exposure. This may cause pronounced progestogenic effects.
What this interaction means in plain words
Levoketoconazole and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Progesterone belongs to Endocrine.
Why it happens
Levoketoconazole strongly inhibits CYP3A4 metabolism of progesterone.
What to do
Monitor for excess progestogenic effects such as sedation and bleeding changes, and reduce the progesterone dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Progesterone?
MediHelp rates the interaction as moderate. Levoketoconazole and Progesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and can substantially increase progesterone exposure. This may cause pronounced progestogenic effects.
How serious is the interaction between Levoketoconazole and Progesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess progestogenic effects such as sedation and bleeding changes, and reduce the progesterone dose if they occur.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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