Drug interactions
Levoketoconazole + Sucralfate
Severity: Moderate
Levoketoconazole and Sucralfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole needs gastric acidity to dissolve and absorb. Sucralfate raises gastric pH slightly and may bind drugs, possibly reducing absorption and cortisol-lowering efficacy.
What this interaction means in plain words
Levoketoconazole and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Sucralfate belongs to Gastrointestinal Tract.
Why it happens
Reduced oral absorption through binding and decreased gastric acidity.
What to do
Separate administration by at least 2 hours, giving levoketoconazole first, and monitor cortisol control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sucralfate
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Sucralfate?
MediHelp rates the interaction as moderate. Levoketoconazole and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole needs gastric acidity to dissolve and absorb. Sucralfate raises gastric pH slightly and may bind drugs, possibly reducing absorption and cortisol-lowering efficacy.
How serious is the interaction between Levoketoconazole and Sucralfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate administration by at least 2 hours, giving levoketoconazole first, and monitor cortisol control.
What other medicines interact with Sucralfate?
MediHelp also lists interactions of Sucralfate with, for example, Ciprofloxacin, Gemifloxacin, Levofloxacin. The full list is on the Sucralfate page.
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