Drug interactions
Levoketoconazole + Ticlopidine
Severity: Moderate
Levoketoconazole and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a potent CYP3A4 inhibitor and may raise ticlopidine concentrations. Ticlopidine also depends on other pathways, so the effect is uncertain, but ticlopidine toxicity (neutropenia, thrombocytopenia, TTP) is serious. Levoketoconazole also carries hepatotoxicity and QT risks.
What this interaction means in plain words
Levoketoconazole and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levoketoconazole belongs to Endocrine; Ticlopidine belongs to Cardiovascular.
Why it happens
Levoketoconazole inhibits CYP3A4, reducing ticlopidine clearance.
What to do
Monitor complete blood counts closely and watch for bleeding or hematologic toxicity. Consider an alternative antiplatelet if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticlopidine
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Levoketoconazole with Ticlopidine?
MediHelp rates the interaction as moderate. Levoketoconazole and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a potent CYP3A4 inhibitor and may raise ticlopidine concentrations. Ticlopidine also depends on other pathways, so the effect is uncertain, but ticlopidine toxicity (neutropenia, thrombocytopenia, TTP) is serious. Levoketoconazole also carries hepatotoxicity and QT risks.
How serious is the interaction between Levoketoconazole and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely and watch for bleeding or hematologic toxicity. Consider an alternative antiplatelet if toxicity appears.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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