Drug interactions
Liothyronine + Trimipramine
Severity: Moderate
Liothyronine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormones may increase the sensitivity of the cardiovascular system to catecholamines and enhance the effects of tricyclic antidepressants. This can lead to arrhythmias and CNS stimulation, and may also accelerate antidepressant response.
What this interaction means in plain words
Liothyronine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liothyronine belongs to Endocrine; Trimipramine belongs to Central Nervous System.
Why it happens
Increased adrenergic receptor sensitivity with additive cardiovascular and CNS stimulation.
What to do
Monitor heart rate, rhythm and mood, and watch for signs of tricyclic toxicity. Check thyroid function and adjust the doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Liothyronine with Trimipramine?
MediHelp rates the interaction as moderate. Liothyronine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormones may increase the sensitivity of the cardiovascular system to catecholamines and enhance the effects of tricyclic antidepressants. This can lead to arrhythmias and CNS stimulation, and may also accelerate antidepressant response.
How serious is the interaction between Liothyronine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and mood, and watch for signs of tricyclic toxicity. Check thyroid function and adjust the doses as needed.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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