Drug interactions
Liposomal doxorubicin + Rolapitant
Severity: Minor
Liposomal doxorubicin and Rolapitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rolapitant inhibits CYP2D6 for a prolonged period, and doxorubicin is partly metabolized by CYP2D6 to doxorubicinol. Exposure changes are of uncertain clinical significance, since CYP2D6 is not a major route.
What this interaction means in plain words
Liposomal doxorubicin and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Liposomal doxorubicin belongs to Oncology; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Long-lasting CYP2D6 inhibition by rolapitant may modestly alter doxorubicin metabolism.
What to do
No dose change is generally needed; monitor for increased myelosuppression and mucositis.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Frequently asked questions
Can I take Liposomal doxorubicin with Rolapitant?
MediHelp rates the interaction as minor. Liposomal doxorubicin and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rolapitant inhibits CYP2D6 for a prolonged period, and doxorubicin is partly metabolized by CYP2D6 to doxorubicinol. Exposure changes are of uncertain clinical significance, since CYP2D6 is not a major route.
How serious is the interaction between Liposomal doxorubicin and Rolapitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for increased myelosuppression and mucositis.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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