Drug interactions
Lisdexamfetamine + Melatonin
Severity: Minor
Lisdexamfetamine and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin promotes sleep while lisdexamfetamine is a stimulant that causes insomnia, so the two have opposing effects on alertness. Melatonin may partly offset stimulant-related sleep disturbance, and the stimulant may blunt melatonin's hypnotic effect. There is no significant safety concern.
What this interaction means in plain words
Lisdexamfetamine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lisdexamfetamine belongs to Central Nervous System; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Opposing pharmacodynamic effects on sleep and wakefulness; no pharmacokinetic interaction is established.
What to do
No dose change is needed; give lisdexamfetamine in the morning and melatonin at bedtime. Reassess sleep quality at follow-up.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Lisdexamfetamine with Melatonin?
MediHelp rates the interaction as minor. Lisdexamfetamine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin promotes sleep while lisdexamfetamine is a stimulant that causes insomnia, so the two have opposing effects on alertness. Melatonin may partly offset stimulant-related sleep disturbance, and the stimulant may blunt melatonin's hypnotic effect. There is no significant safety concern.
How serious is the interaction between Lisdexamfetamine and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; give lisdexamfetamine in the morning and melatonin at bedtime. Reassess sleep quality at follow-up.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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