Drug interactions
Lisdexamfetamine + Methamphetamine
Severity: Major
Lisdexamfetamine and Methamphetamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are amphetamine-type stimulants, so combining them produces additive sympathomimetic effects, including higher blood pressure, tachycardia, insomnia, anxiety and a greater risk of abuse. Duplicate therapy has no clear rationale and raises cardiovascular risk.
What this interaction means in plain words
Lisdexamfetamine and Methamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lisdexamfetamine belongs to Central Nervous System; Methamphetamine belongs to Central Nervous System.
Why it happens
Additive release of norepinephrine and dopamine and inhibition of their reuptake (duplicate pharmacodynamic action).
What to do
Avoid concurrent use and prescribe a single stimulant. If a switch is made, stop one before starting the other and monitor blood pressure and heart rate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Methamphetamine?
MediHelp rates the interaction as major. Lisdexamfetamine and Methamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are amphetamine-type stimulants, so combining them produces additive sympathomimetic effects, including higher blood pressure, tachycardia, insomnia, anxiety and a greater risk of abuse. Duplicate therapy has no clear rationale and raises cardiovascular risk.
How serious is the interaction between Lisdexamfetamine and Methamphetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and prescribe a single stimulant. If a switch is made, stop one before starting the other and monitor blood pressure and heart rate.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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