Drug interactions
Lisdexamfetamine + Modafinil
Severity: Moderate
Lisdexamfetamine and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents promote wakefulness, so combined use may cause additive stimulation such as insomnia, anxiety, irritability, and increases in heart rate or blood pressure. Modafinil may also modestly delay the absorption of amphetamines.
What this interaction means in plain words
Lisdexamfetamine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisdexamfetamine belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Additive CNS stimulation via dopaminergic and noradrenergic pathways.
What to do
Monitor blood pressure, heart rate and sleep when used together. Use the lowest effective doses and avoid evening dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lisdexamfetamine and Modafinil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Modafinil
Frequently asked questions
Can I take Lisdexamfetamine with Modafinil?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents promote wakefulness, so combined use may cause additive stimulation such as insomnia, anxiety, irritability, and increases in heart rate or blood pressure. Modafinil may also modestly delay the absorption of amphetamines.
How serious is the interaction between Lisdexamfetamine and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sleep when used together. Use the lowest effective doses and avoid evening dosing.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
