Drug interactions
Lisdexamfetamine + Oxycodone
Severity: Minor
Lisdexamfetamine and Oxycodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stimulants may mask opioid-induced drowsiness without reversing respiratory depression, and both can affect cardiovascular parameters. A clinically significant pharmacokinetic interaction is not established.
What this interaction means in plain words
Lisdexamfetamine and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lisdexamfetamine belongs to Central Nervous System; Oxycodone belongs to Musculoskeletal.
Why it happens
Opposing CNS effects with possible additive sympathomimetic and serotonergic activity; no established pharmacokinetic mechanism.
What to do
Do not use alertness alone to judge opioid safety; monitor respiratory rate and cardiovascular status when doses change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Oxycodone?
MediHelp rates the interaction as minor. Lisdexamfetamine and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stimulants may mask opioid-induced drowsiness without reversing respiratory depression, and both can affect cardiovascular parameters. A clinically significant pharmacokinetic interaction is not established.
How serious is the interaction between Lisdexamfetamine and Oxycodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use alertness alone to judge opioid safety; monitor respiratory rate and cardiovascular status when doses change.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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