Drug interactions
Lisdexamfetamine + Ozanimod
Severity: Major
Lisdexamfetamine and Ozanimod: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolite inhibits MAO-B in vitro, so combining it with amphetamine from lisdexamfetamine may cause excessive norepinephrine and serotonin effects. This may lead to hypertensive crisis or serotonin syndrome.
What this interaction means in plain words
Lisdexamfetamine and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lisdexamfetamine belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
MAO inhibition by an ozanimod metabolite potentiates amphetamine-induced monoamine release.
What to do
Avoid the combination. If it cannot be avoided, monitor blood pressure and heart rate closely and watch for serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Ozanimod?
MediHelp rates the interaction as major. Lisdexamfetamine and Ozanimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ozanimod's active metabolite inhibits MAO-B in vitro, so combining it with amphetamine from lisdexamfetamine may cause excessive norepinephrine and serotonin effects. This may lead to hypertensive crisis or serotonin syndrome.
How serious is the interaction between Lisdexamfetamine and Ozanimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If it cannot be avoided, monitor blood pressure and heart rate closely and watch for serotonin toxicity.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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