Drug interactions
Lisdexamfetamine + Propylhexedrine
Severity: Moderate
Lisdexamfetamine and Propylhexedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is a sympathomimetic nasal decongestant and lisdexamfetamine is an amphetamine prodrug. Together they can produce additive increases in blood pressure and heart rate, along with stimulation such as insomnia, tremor and anxiety.
What this interaction means in plain words
Lisdexamfetamine and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisdexamfetamine belongs to Central Nervous System; Propylhexedrine belongs to Respiratory.
Why it happens
Additive indirect sympathomimetic activity through release of norepinephrine and other catecholamines.
What to do
Avoid routine use of decongestants with lisdexamfetamine, and choose non-sympathomimetic alternatives such as saline or intranasal corticosteroids. If used, monitor blood pressure and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Lisdexamfetamine with Propylhexedrine?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Propylhexedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propylhexedrine is a sympathomimetic nasal decongestant and lisdexamfetamine is an amphetamine prodrug. Together they can produce additive increases in blood pressure and heart rate, along with stimulation such as insomnia, tremor and anxiety.
How serious is the interaction between Lisdexamfetamine and Propylhexedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine use of decongestants with lisdexamfetamine, and choose non-sympathomimetic alternatives such as saline or intranasal corticosteroids. If used, monitor blood pressure and heart rate.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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