Drug interactions
Lisdexamfetamine + Rizatriptan
Severity: Moderate
Lisdexamfetamine and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines enhance serotonergic and noradrenergic transmission and triptans are 5-HT1B/1D agonists, so serotonin syndrome is a theoretical risk, although reports are rare. Both can also raise blood pressure.
What this interaction means in plain words
Lisdexamfetamine and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisdexamfetamine belongs to Central Nervous System; Rizatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic activity and additive vasoconstrictive or pressor effects.
What to do
Counsel patients to report agitation, tremor, fever, diarrhea or confusion. Monitor blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Rizatriptan?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines enhance serotonergic and noradrenergic transmission and triptans are 5-HT1B/1D agonists, so serotonin syndrome is a theoretical risk, although reports are rare. Both can also raise blood pressure.
How serious is the interaction between Lisdexamfetamine and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report agitation, tremor, fever, diarrhea or confusion. Monitor blood pressure.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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