Drug interactions
Lisdexamfetamine + Sevoflurane
Severity: Moderate
Lisdexamfetamine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisdexamfetamine is converted to dextroamphetamine, which increases catecholamine release, and volatile anesthetics can sensitize the myocardium to catecholamines. During anesthesia this may cause hypertension, tachycardia or ventricular arrhythmias, though data are limited.
What this interaction means in plain words
Lisdexamfetamine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisdexamfetamine belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Pharmacodynamic additive sympathomimetic effects with anesthetic-related myocardial sensitization to catecholamines.
What to do
Inform the anesthesia team of recent stimulant use and monitor blood pressure and ECG continuously. Treat hemodynamic surges per standard practice and consider holding the stimulant on the day of surgery per institutional protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Lisdexamfetamine with Sevoflurane?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lisdexamfetamine is converted to dextroamphetamine, which increases catecholamine release, and volatile anesthetics can sensitize the myocardium to catecholamines. During anesthesia this may cause hypertension, tachycardia or ventricular arrhythmias, though data are limited.
How serious is the interaction between Lisdexamfetamine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of recent stimulant use and monitor blood pressure and ECG continuously. Treat hemodynamic surges per standard practice and consider holding the stimulant on the day of surgery per institutional protocol.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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