Drug interactions
Lisdexamfetamine + Tedizolid
Severity: Moderate
Lisdexamfetamine and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisdexamfetamine is converted to dextroamphetamine, which releases monoamines, and MAO inhibition slows their breakdown. Tedizolid is only a weak MAO inhibitor, so the hypertensive and serotonergic risk is lower than with classic MAO inhibitors.
What this interaction means in plain words
Lisdexamfetamine and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisdexamfetamine belongs to Central Nervous System; Tedizolid belongs to Anti Bacterial.
Why it happens
Amphetamine-induced monoamine release combined with weak reversible MAO inhibition.
What to do
Monitor blood pressure, heart rate and mental status during co-administration, and consider an alternative antibiotic in patients with significant cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Lisdexamfetamine with Tedizolid?
MediHelp rates the interaction as moderate. Lisdexamfetamine and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lisdexamfetamine is converted to dextroamphetamine, which releases monoamines, and MAO inhibition slows their breakdown. Tedizolid is only a weak MAO inhibitor, so the hypertensive and serotonergic risk is lower than with classic MAO inhibitors.
How serious is the interaction between Lisdexamfetamine and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and mental status during co-administration, and consider an alternative antibiotic in patients with significant cardiovascular disease.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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