Drug interactions
Lomustine + Siltuximab
Severity: Moderate
Lomustine and Siltuximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Siltuximab blocks IL-6 and can raise infection risk while masking fever and CRP. With myelosuppressive lomustine, infections may be more frequent and harder to detect.
What this interaction means in plain words
Lomustine and Siltuximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomustine belongs to Oncology; Siltuximab belongs to Miscellaneous.
Why it happens
Additive immunosuppression from IL-6 blockade and cytotoxic marrow suppression.
What to do
Monitor blood counts and screen for infection with a low threshold, since CRP and fever may be blunted. Hold siltuximab during serious infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Siltuximab
- Baricitinib + Siltuximab Major
- Atorvastatin + Siltuximab Moderate
- Carbamazepine + Siltuximab Moderate
- Cyclosporin + Siltuximab Moderate
- Ethinyl estradiol-drospirenone + Siltuximab Moderate
- Ethinyl estradiol-levonorgestrel + Siltuximab Moderate
Frequently asked questions
Can I take Lomustine with Siltuximab?
MediHelp rates the interaction as moderate. Lomustine and Siltuximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Siltuximab blocks IL-6 and can raise infection risk while masking fever and CRP. With myelosuppressive lomustine, infections may be more frequent and harder to detect.
How serious is the interaction between Lomustine and Siltuximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and screen for infection with a low threshold, since CRP and fever may be blunted. Hold siltuximab during serious infection.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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