Drug interactions
Lomustine + Vedolizumab
Severity: Moderate
Lomustine and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine is a myelosuppressive alkylating agent with delayed and prolonged marrow toxicity. With vedolizumab, infection risk may rise, particularly gastrointestinal infections.
What this interaction means in plain words
Lomustine and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomustine belongs to Oncology; Vedolizumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression from delayed myelosuppression and gut-selective lymphocyte trafficking blockade.
What to do
Monitor complete blood counts, including nadir counts several weeks after lomustine, and evaluate promptly for infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Lomustine with Vedolizumab?
MediHelp rates the interaction as moderate. Lomustine and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomustine is a myelosuppressive alkylating agent with delayed and prolonged marrow toxicity. With vedolizumab, infection risk may rise, particularly gastrointestinal infections.
How serious is the interaction between Lomustine and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts, including nadir counts several weeks after lomustine, and evaluate promptly for infection.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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