Drug interactions
Lonafarnib + Mitomycin
Severity: Minor
Lonafarnib and Mitomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a weak P-glycoprotein inhibitor and may modestly raise exposure to mitomycin. The clinical relevance is uncertain, but mitomycin has a narrow therapeutic margin.
What this interaction means in plain words
Lonafarnib and Mitomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonafarnib belongs to Miscellaneous; Mitomycin belongs to Oncology.
Why it happens
Weak inhibition of P-glycoprotein efflux by lonafarnib may increase mitomycin levels.
What to do
Monitor blood counts and for adverse reactions to mitomycin. Reduce the mitomycin dose if toxicity occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Mitomycin?
MediHelp rates the interaction as minor. Lonafarnib and Mitomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a weak P-glycoprotein inhibitor and may modestly raise exposure to mitomycin. The clinical relevance is uncertain, but mitomycin has a narrow therapeutic margin.
How serious is the interaction between Lonafarnib and Mitomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for adverse reactions to mitomycin. Reduce the mitomycin dose if toxicity occurs.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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