Drug interactions
Lonafarnib + Tenofovir alafenamide
Severity: Minor
Lonafarnib and Tenofovir alafenamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a weak P-glycoprotein inhibitor, and tenofovir alafenamide is a P-gp substrate whose absorption depends on this transporter. A small increase in tenofovir exposure is possible but unlikely to be clinically important.
What this interaction means in plain words
Lonafarnib and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonafarnib belongs to Miscellaneous; Tenofovir alafenamide belongs to Anti Virals.
Why it happens
Weak inhibition of intestinal P-gp efflux by lonafarnib, increasing tenofovir alafenamide absorption.
What to do
No dose adjustment is usually necessary. Monitor for tenofovir adverse effects and renal function as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lonafarnib and Tenofovir alafenamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tenofovir alafenamide
- Apalutamide + Tenofovir alafenamide Major
- Berotralstat + Tenofovir alafenamide Moderate
- Danicopan + Tenofovir alafenamide Moderate
- Ifosfamide + Tenofovir alafenamide Moderate
- Orlistat + Tenofovir alafenamide Moderate
- Sotorasib + Tenofovir alafenamide Moderate
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Tenofovir alafenamide?
MediHelp rates the interaction as minor. Lonafarnib and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a weak P-glycoprotein inhibitor, and tenofovir alafenamide is a P-gp substrate whose absorption depends on this transporter. A small increase in tenofovir exposure is possible but unlikely to be clinically important.
How serious is the interaction between Lonafarnib and Tenofovir alafenamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually necessary. Monitor for tenofovir adverse effects and renal function as routine.
What other medicines interact with Tenofovir alafenamide?
MediHelp also lists interactions of Tenofovir alafenamide with, for example, Apalutamide, Berotralstat, Danicopan. The full list is on the Tenofovir alafenamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
