Drug interactions
Lopinavir + Medroxyprogesterone
Severity: Moderate
Lopinavir and Medroxyprogesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, co-formulated with ritonavir, inhibits CYP3A4 and may increase medroxyprogesterone exposure. Increased progestin adverse effects are possible, although data are limited.
What this interaction means in plain words
Lopinavir and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Medroxyprogesterone belongs to Endocrine.
Why it happens
Ritonavir-boosted lopinavir inhibits CYP3A4 metabolism of medroxyprogesterone.
What to do
Monitor for progestogenic adverse effects and glycemic changes. Adjust the hormonal regimen if tolerability is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Medroxyprogesterone
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Medroxyprogesterone?
MediHelp rates the interaction as moderate. Lopinavir and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir, co-formulated with ritonavir, inhibits CYP3A4 and may increase medroxyprogesterone exposure. Increased progestin adverse effects are possible, although data are limited.
How serious is the interaction between Lopinavir and Medroxyprogesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestogenic adverse effects and glycemic changes. Adjust the hormonal regimen if tolerability is poor.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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