Drug interactions
Lopinavir + Vilazodone
Severity: Moderate
Lopinavir and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, given with ritonavir, inhibits CYP3A4 and can raise vilazodone exposure. Higher levels may increase serotonergic and gastrointestinal adverse effects.
What this interaction means in plain words
Lopinavir and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Vilazodone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of vilazodone by the ritonavir-boosted lopinavir.
What to do
Monitor for serotonergic adverse effects and nausea or diarrhea. Reduce the vilazodone dose to 20 mg daily if intolerable effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Vilazodone?
MediHelp rates the interaction as moderate. Lopinavir and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir, given with ritonavir, inhibits CYP3A4 and can raise vilazodone exposure. Higher levels may increase serotonergic and gastrointestinal adverse effects.
How serious is the interaction between Lopinavir and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonergic adverse effects and nausea or diarrhea. Reduce the vilazodone dose to 20 mg daily if intolerable effects occur.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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