Drug interactions
Loratadine + Metoclopramide
Severity: Minor
Loratadine and Metoclopramide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loratadine is a minimally sedating antihistamine with no known meaningful interaction with metoclopramide. No clinically significant effect is expected.
What this interaction means in plain words
Loratadine and Metoclopramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Loratadine belongs to Respiratory; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
No established pharmacokinetic or pharmacodynamic mechanism.
What to do
No specific action is needed beyond routine monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoclopramide
Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Frequently asked questions
Can I take Loratadine with Metoclopramide?
MediHelp rates the interaction as minor. Loratadine and Metoclopramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Loratadine is a minimally sedating antihistamine with no known meaningful interaction with metoclopramide. No clinically significant effect is expected.
How serious is the interaction between Loratadine and Metoclopramide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine monitoring.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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