Drug interactions
Loratadine + Posaconazole
Severity: Minor
Loratadine and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor and P-gp inhibitor and may raise loratadine and desloratadine exposure. Because loratadine has a wide therapeutic margin, the clinical impact is usually small.
What this interaction means in plain words
Loratadine and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Loratadine belongs to Respiratory; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by posaconazole reduces loratadine clearance.
What to do
No routine dose change is needed; watch for increased sedation or palpitations and consider an alternative antihistamine if troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Loratadine with Posaconazole?
MediHelp rates the interaction as minor. Loratadine and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole is a strong CYP3A4 inhibitor and P-gp inhibitor and may raise loratadine and desloratadine exposure. Because loratadine has a wide therapeutic margin, the clinical impact is usually small.
How serious is the interaction between Loratadine and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for increased sedation or palpitations and consider an alternative antihistamine if troublesome.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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