Drug interactions
Loratadine + Tepotinib
Severity: Minor
Loratadine and Tepotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein and may raise loratadine exposure. Given loratadine's wide therapeutic index, the effect is expected to be mild.
What this interaction means in plain words
Loratadine and Tepotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Loratadine belongs to Respiratory; Tepotinib belongs to Oncology.
Why it happens
P-gp inhibition by tepotinib reduces loratadine efflux.
What to do
No dose change is usually required. Monitor for adverse effects such as sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Loratadine with Tepotinib?
MediHelp rates the interaction as minor. Loratadine and Tepotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tepotinib inhibits P-glycoprotein and may raise loratadine exposure. Given loratadine's wide therapeutic index, the effect is expected to be mild.
How serious is the interaction between Loratadine and Tepotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Monitor for adverse effects such as sedation.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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