Drug interactions
Magnesium hydroxide + Vismodegib
Severity: Minor
Magnesium hydroxide and Vismodegib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vismodegib has pH-dependent solubility, so drugs that raise gastric pH may reduce its bioavailability. The labeling indicates that the clinical effect on efficacy is not known.
What this interaction means in plain words
Magnesium hydroxide and Vismodegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Magnesium hydroxide belongs to Gastrointestinal Tract; Vismodegib belongs to Oncology.
Why it happens
Higher gastric pH may lower vismodegib solubility and absorption, but the clinical impact is uncertain.
What to do
No routine dose change is required. Monitor tumor response and consider spacing the antacid from vismodegib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Magnesium hydroxide
Other interactions of Vismodegib
- Dexlansoprazole + Vismodegib Moderate
- Esomeprazole + Vismodegib Moderate
- Famotidine + Vismodegib Moderate
- Omeprazole + Vismodegib Moderate
- Pantoprazole + Vismodegib Moderate
- Aluminum hydroxide + Vismodegib Minor
Frequently asked questions
Can I take Magnesium hydroxide with Vismodegib?
MediHelp rates the interaction as minor. Magnesium hydroxide and Vismodegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vismodegib has pH-dependent solubility, so drugs that raise gastric pH may reduce its bioavailability. The labeling indicates that the clinical effect on efficacy is not known.
How serious is the interaction between Magnesium hydroxide and Vismodegib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required. Monitor tumor response and consider spacing the antacid from vismodegib.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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