Drug interactions
Magnesium sulphate + Metolazone
Severity: Minor
Magnesium sulphate and Metolazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone increases urinary magnesium loss and may cause hypomagnesemia, especially when combined with loop diuretics. This can offset magnesium supplementation and add to arrhythmia risk.
What this interaction means in plain words
Magnesium sulphate and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Magnesium sulphate belongs to Cardiovascular; Metolazone belongs to Cardiovascular.
Why it happens
Inhibition of distal tubular sodium chloride reabsorption increases renal magnesium excretion.
What to do
Monitor serum magnesium and potassium regularly, particularly with combined diuretic therapy, and replace as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Magnesium sulphate
- Amikacin + Magnesium sulphate Moderate
- Amphotericin b deoxycholate + Magnesium sulphate Moderate
- Atracurium + Magnesium sulphate Moderate
- Baloxavir marboxil + Magnesium sulphate Moderate
- Ciprofloxacin + Magnesium sulphate Moderate
- Cisatracurium + Magnesium sulphate Moderate
Other interactions of Metolazone
Frequently asked questions
Can I take Magnesium sulphate with Metolazone?
MediHelp rates the interaction as minor. Magnesium sulphate and Metolazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metolazone increases urinary magnesium loss and may cause hypomagnesemia, especially when combined with loop diuretics. This can offset magnesium supplementation and add to arrhythmia risk.
How serious is the interaction between Magnesium sulphate and Metolazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and potassium regularly, particularly with combined diuretic therapy, and replace as needed.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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