Drug interactions
Maraviroc + Methylprednisolone
Severity: Minor
Maraviroc and Methylprednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids may weakly induce CYP3A4, which could slightly lower maraviroc concentrations. Short courses are unlikely to matter, but prolonged high doses might reduce antiretroviral activity.
What this interaction means in plain words
Maraviroc and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Maraviroc belongs to Anti Virals; Methylprednisolone belongs to Endocrine.
Why it happens
Possible weak CYP3A4 induction by methylprednisolone increasing maraviroc metabolism; the effect is theoretical.
What to do
No empirical maraviroc dose change is needed; monitor HIV viral load if prolonged high-dose steroid therapy is given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Maraviroc with Methylprednisolone?
MediHelp rates the interaction as minor. Maraviroc and Methylprednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Corticosteroids may weakly induce CYP3A4, which could slightly lower maraviroc concentrations. Short courses are unlikely to matter, but prolonged high doses might reduce antiretroviral activity.
How serious is the interaction between Maraviroc and Methylprednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical maraviroc dose change is needed; monitor HIV viral load if prolonged high-dose steroid therapy is given.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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